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KMID : 0363420170310030037
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Journal of Korean Oriental Pediatrics
2017 Volume.31 No. 3 p.37 ~ p.45
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A Comparative Study of Douchi Hataedock versus Omega-3 on the Effect of Anti-inflammation in the Colonic Muscle through Th2 Skewed Condition Control
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Ahn Sang-Hyun
Kim Ki-Bong
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Abstract
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Objectives: Hataedock is an orally-administered herbal extract that used to treat toxic heat and help excrete meconium
accumulates in the fetus from pregnancy. This study compared the effects of Hataedock using the extract of Douchi
and omega-3 to control inflammation in the colonic mucosa.
Methods: NC/Nga mice were divided into three groups; Control group (no treatment), FGT group (given the extract of
Douchi), and O3T group (given omega-3). The 3-week-old mouse from each group were given the extract of Douchi
and omega-3. After 2 weeks, the colonic mucosa tissues of the mice were observed via Immunohistochemical
staining for IL-4, IL-13, CD40, FcεRI, p-IκB, EGF in the intestinal mucosa.
Results: In both FGT and O3T group, IL-4, IL-13, STAT-6 levels and CD40-positive reactions were decreased. However,
EGF-positive responses were increased. FGT group showed 35% decrease in IL-4, 45% decrease in IL-13, 48%
decrease in CD40, 50% decrease in Fc?RI, 54% decrease in p-IκB, 52% increase in EGF compared to the control
group. O3T group also showed 14% decrease in IL-4, 23% decrease in IL-13, 22% decrease in CD40, 29% decrease
in Fc?RI, 41% decrease in p-IκB, 39% increase in EGF compared to the control group.
Conclusions: Both early administration of Douchi extract and omega-3 were effective in regulating Th2, relieving inflammation and developing colonic mucosal tissues. Hataedock with Douchi extract may be more effective in modulating
immune system in colonic mucosa than omega-3.
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KEYWORD
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Hataedock, Douchi, Colonic mucosa, Omega-3, Th2 skewed condition, Inflamma
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